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Acknowledgements Funding This manuscript, including the journals Rapid Service and Open Access Fees, was supported by Meda Pharma SpA

Endothelial cells associated with tumors secrete growth factors such as vascular endothelial growth factor (VEGF), Notch ligands, and nitric oxide, which enables the cancer cells proliferation and self-renewal (127)

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Omega-3 Polyunsaturated Fatty Acids (Omega-3 or n-3 PUFAs) , eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), are broad-spectrum anti-inflammatory compounds that modulate several pathways of inflammation including leukocyte chemotaxis, adhesion molecule expression, and leukocyte-endothelial adhesive interactions, inflammatory cytokine synthesis and T cell reactivity 708

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