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Results from recent published meta-analyses of observational studies are reported in Table 1 (adapted from 23)

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For both iron and potassium, the resulting decline in serum concentrations may be large enough to induce clinical deficiency states, including increased risk of death from cardiac failure due to hypokalemia (56)

TRPM4 is a non-selective, Ca 2+ -impermeable channel that exclusively transports monovalent cations