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Platinum generally triggers apoptosis via the intrinsic pathway initiated at the level of the mitochondria via induction of BAX and BAK through TP53 -dependent or MAPK-dependent pathways [40]

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Akt: protein kinase B

More importantly, the increasing of iron uptake caused by CD44 overexpression and the decreasing iron efflux caused by downregulating FPN in CSCs cause intracellular iron to be higher than non-CSCs

Intracellular degrading enzymes ChaC1 and ChaC2 play a key role in downregulating intracellular GSH levels, exerting a counteractive effect to regulate intracellular GSH homeostasis