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All research applications described above are drawn from preclinical animal and in vitro studies

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In addition, a significant reduction in orthostatic blood pressure in the metformin group indicated a worsening of cardiovascular autonomic neuropathy[44]

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REIMAGINE 2 a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema 2.4 mg/2.4 mg versus semaglutide 2.4 mg, cagrilintide 2.4 mg, and placebo, and CagriSema 1.0 mg/1.0 mg versus semaglutide 1.0 mg and placebo in 2,728 adults with type 2 diabetes inadequately controlled with metformin with or without an SGLT2 inhibitor

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