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MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]

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[DOI] [PubMed] [Google Scholar] 46.Volpato S, Bianchi L, Cherubini A, Landi F, Maggio M, Savino E, Bandinelli S, Ceda GP, Guralnik JM, Zuliani G, et al

doi: 10.1016/j.semcdb.2017.05.023 83 HuaHKongQZhangHWangJLuoTJiangY

When L-dopa is administered as a single agent, it may deplete serotonin, and would then be considered a drug, not a nutrient

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