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Results: Vitamin B12 supplementation was associated with a significant increase in serum cobalamin levels across all routes of administration (pooled mean difference = +402.6 pg/mL

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Only one patient did not tolerate the oral form

28,29 Vitamin B 6 serves as a cofactor to more than 140 enzymes, it is required for tryptophan metabolism and synthesis of nicotinic acid, and it is a cofactor for alanine aminotransferase and aspartate aminotransferase

When combined with 6 mg hyaluronic acid, the effects were significantly enhanced beyond either treatment alone