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Ultimately, resolving this controversy requires research that integrates multiple complementary techniqueshigh-resolution spatial metabolomics, genetically encoded biosensors in specific cell types, and advanced in vivo imagingto simultaneously quantify metabolic fluxes, compartmentalization, and cellular interactions with high temporal and spatial precision

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Upper right: Common purslane flowers (Antonio DiTommaso, Cornell University)

Introduction Altered fluxes through the metabolic pathways of glucose are of major interest in different pathologies, e.g

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