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The typical gradient was 10% to 40% component B over 30 minutes at a flow rate of 1 ml/min at 37C where component A was 80 mM triethy amine phosphate, pH 3.0 and component B was acetonitrile (ACN)
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To investigate whether QMP would secure a long plasma half-life of a GLP-1 albumin fusion, we constructed a recombinant fusion protein with the identical amino acid sequence as Tanzeum (albiglutide-mimic: GLP-1 WT), as well as a modified version containing the QMP substitutions (GLP-1 QMP) (Fig

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