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Trigonelline Trigonelline is a naturally occurring pyridine alkaloid that is a major constituent of the herb Mirabilis jalapa L

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NFE2L2 plays a pivotal role in regulating antioxidant genes involved in both GPX4-dependent (e.g., GPX4 and SLC7A11) and GPX4 independent pathways (e.g., AIFM2 and MT1G [metallothionein 1G]) [34, 83, 156]

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