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This process involves nitric acid oxidation, which introduced hydrophilic carboxyl groups onto the CQD surface, improving aqueous solubility and resulting in a broad particle size distribution, with a QY of approximately 1.66% under 366 nm excitation

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US20210186943A1 - Otic formulations for drug-induced ototoxicity - Google Patents Otic formulations for drug-induced ototoxicity Download PDF Info Publication number US20210186943A1 US20210186943A1 US17/050,421 US201917050421A US2021186943A1 US 20210186943 A1 US20210186943 A1 US 20210186943A1 US 201917050421 A US201917050421 A US 201917050421A US 2021186943 A1 US2021186943 A1 US 2021186943A1 Authority US United States Prior art keywords formulation otic composition therapeutic agent agent Prior art date Legal status (The legal status is an assumption and is not a legal conclusion

The name reflects the historical context of its original characterization, although later research has expanded interest in DSIP beyond its initial classification

A: The injection should be stored in a cool, dry place as per the manufacturer's guidelines to preserve its efficacy and shelf life

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