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Pernigoni et al (15) demonstrated, through metagenomic sequencing, a marked enrichment of bacterial strains (for example, certain Ruminococcaceae species) capable of encoding enzymes involved in androgen biosynthesis, such as androstenedione, in the fecal microbiota of men with CRPC

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Focusing on direct transcriptional targets of NHR-49 with its established roles in lipid metabolism 34,35,36,37,38,39,40,41 , we confirmed that fasting-induced activation of the mitochondrial medium-chain acyl-CoA ligase ( acs-2) and repression of the stearoyl-CoA desaturase ( fat-7) were both abrogated in the loss-of-function nhr-49(nr2041) mutant animals (Fig