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Description
Intracellular redox changes affect cell signaling, gene transcription, proliferation, and apoptosis

10.1021/acs.jpcc.5b08558 44 ZhouZ

IDH1/2 use NADP + as a cofactor and conduct a reversible reaction, while IDH3 uses NAD + as a cofactor and conducts irreversible conversion

Delgado-Prudencio et al., 2022)

Combination treatments are often required

Pero eso no es todo
