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Temporary inflammation is not dangerous, but if neuroinflammation continues and causes damage to neurons, synaptic dysfunction, and relentless neurodegeneration, it becomes dangerous

Rather, it reflects an indirect effect mediated through alterations in the skin's microbial ecosystem

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Neumann, J

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Limitations of Included Studies Most of the studies did not report baseline ascorbate concentrations [17, 18, 20, 22, 23, 24], and some reported only very low baseline values [17, 19], which could reflect issues with sample processing, storage or analysis [28], for example storage of plasma samples at 20 C rather than 80 C [19]