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developed a small activating RNA drug called MTL-CEBPA, and preclinical studies (phase I trials) showed that MTL-CEBPA not only inhibited the proliferation of hepatocellular carcinoma cells and induced apoptosis, but also reversed the immune-suppressing properties of M-MDSC and TAM, and facilitated the transition of TAM to anti-tumor M1 phenotypic polarization opens up new avenues for the treatment of hepatocellular carcinoma and is expected to bring better therapeutic outcomes for hepatocellular carcinoma patients [105]

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