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Recombinant hGH therapy is contraindicated in patients with untreated diabetes, a history of cancer, increased intracranial pressure, carpal tunnel syndrome, edema, sleep apnea, and pancreatitis

These include 1 ) the mitochondrial glycerol 3-phosphate dehydrogenase (G3PDH), a part of the glycerophosphate shuttle (75), 2 ) the mitochondrial dihydroorotate dehydrogenase (DHODH), an enzyme involved in a key step in the production of pyrimidine nucleotides (76), 3 ) the electron transport flavoprotein dehydrogenase (ETFDH), a key enzyme of fatty acid -oxidation and amino acid catabolism, 4 ) proline dehydrogenase (PRODH) and proline dehydrogenase 2 (PRODH2), both of which are involved in proline, glyoxylate, and arginine metabolism, 5 ) choline dehydrogenase (CHDH), which is primarily found in liver and kidney in humans and catalyzes the oxidation of choline to glycine betaine (77), and 6 ) sulfide-quinone oxidoreductase (SQOR), which is essential for detoxification of hydrogen sulfide (H 2 S) (78)

GHK-Cu, a naturally occurring copper-binding tripeptide found in human plasma, operates through copper-mediated gene modulation and has found practical applications in skin rejuvenation and wound care

LC was demonstrated to have a role in ameliorating diabetic neuropathy by decreasing insulin resistance and increasing cellular uptake of glucose (10,11)

Boren, T., P