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The oxidationreduction cycle of iron can also generate free radicals and toxic metabolites (Fig

This architecture ensures the efficient detoxification of reactive oxygen species (ROS) while preserving their essential role as signaling molecules in developmental, physiological, and adaptive processes (Rajput et al

However, the drug can also be modified via phase I metabolism, producing NAPQI, a highly toxic metabolite which is then processed via phase II metabolism to a non-toxic product by the addition of cysteine in a manner dependent on glutathione (Figure 3)

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