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It will be essential to identify combination treatments which would convert CDK4/6-inhibitors from the cytostatic compounds to cytotoxic ones, and would unleash the killing of tumor cells
MAP-2: microtubule associated protein 2
doi: 10.1016/j.ecoenv.2020.111231 35 NishigakiAKidoTKidaNKakita-KobayashiMTsubokuraHHisamatsuYet al
A phase 2 study in classical HCU (ClinicalTrials.gov identifier, NCT05651054) is ongoing, with efficacy data pending
