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1,25-Dihydroxyvitamin D3 reduces cerebral amyloid- accumulation and improves cognition in mouse models of Alzheimers disease

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As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis

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Cohen's d = 0.55

Bretaa y Pars fueron increbles y estuvieron presentes en cada paso del camino