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10.1128/JCM.01121-20 J

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doi: 10.1016/j.yebeh.2019.106848

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However, emerging evidence suggests that building up cysteine-derived antioxidant defense systems also comes at an enormous cost for SLC7A11 high cancer, as such efforts require a significant investment of cellular resources, including glutamate export for exchange of cystine import and NADPH supply to reduce cystine to cysteine in the cytosol, resulting in glucose- and glutamine-dependency in SLC7A11 high cancer cells