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doi: 10.3390/ijms26041670 96 LuoMZhaoFChengHSuMWangY

Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) nonallosteric feedback competitive inhibition by GSH (K i =2.3mM) which involves binding of GSH to the glutamate and another site on the enzyme (Richman and Meister, 1975

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Proc Natl Acad Sci U S A 99(10):67556760 Odorizzi G, Babst M, Emr SD (1998) Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body

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