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The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

5.1 Probiotics and intestinal barrier protection The intestinal epithelium functions as a critical first line of defense, preserving epithelial integrity and shielding the host from pathogenic microorganisms (158)

This is probably due to its effect on learning and memory described above

Clinical and biological significances of a ferroptosis-related gene signature in glioma
