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Collectively, these three axes converge on a unified therapeutic model ( Figure 4 ): H 2 S suppresses pathological NETosis through immediate ROS-MAPK inhibition (Axis 1), intercellular danger signal disruption via platelet-neutrophil crosstalk blockade (Axis 2) and sustained epigenetic reprogramming through miR-16-5p upregulation (Axis 3)

Y.HeF.et al

For BM, 3-fold excess acetonitrile: methanol (3:1) was added for protein removal

It is currently marketed as a dietary supplement, with products like ErgoFlex (OXIS International, Foster City, CA, USA) targeting specific health concerns such as chronic joint pain, cartilage health, and inflammation reduction [18,22]

The link between cortisol and stress was explained

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
