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Several other protein families involved in signal transduction commonly have the PH domain in their structure ( 2+ , is recruited to the plasma membrane to establish the interaction with phosphoinositides ( EF-hand motifs The catalytic core of PLCs is composed of the EF-hand motifs, X and Y domains, and C2 domain ( 2+ leads to a conformational change in the EF-hand motif, as a result of which PLC stabilizes and then exposes the binding site for other proteins to further initiate the calcium-regulated functions and helps in signal transduction ( 2+ promotes the interaction of the PH domain of PLC with PIP2 ( 2+ ( X and Y domains Crystallographic studies of PLC-1, PLC-2, and PLC-3 revealed that the X and Y domains are composed of ~300 amino acids, which lie at the C-terminal of EF-hand motifs ( 311 and His 356 ) as catalytic residues, which are required for the generation of 1,2-cyclic inositol 4,5-bisphosphate ( 311 and His 356 residues are highly conserved across the PLC family members ( C2 domains More than 40 different proteins involved in signal transduction and membrane interactions are reported to have the C2 domain

Metabolites 11:284 Jones OA, Swain SC, Svendsen C, Griffin JL, Sturzenbaum SR, Spurgeon DJ (2012) Potential new method of mixture effects testing using metabolomics and Caenorhabditis elegans

A Naranjo score of 6 was calculated, suggesting that the progressing maculopapular eruption was secondary to pemetrexed and carboplatin exposure [12]

The activity of hypothalamic POMC neurons is also modulated by sex hormones

Stimulate 2

Cancer Discov 11(6):1368-1397, 2021