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Reprogramming in vivo produces teratomas and iPS cells with totipotency features

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Histone H3 acetylation and histone H3 lysine 9 acetylation were significantly reduced in neurons following BTZ treatment (Luczkowska et al., 2022)

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Illustratively, in rats with duodenocolic fistulas, leaking, failure of biomechanical, functional, diarrhea, weight loss, and a long-standing perilous course with cachexia were all counteracted

This has implications for the genetic diagnosis of THAP1 dystonia and supports the use of broader strategies like targeted next generation or whole exome sequencing in this population