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Interestingly, the GSH synthesis machinery has an additional function independent of GSH synthesis under low cysteine conditions, in which -GCL ligates glutamate to other amino acids to scavenge glutamate into -glutamyl peptides and prevent glutamate toxicity [232]

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However, despite the absence of ferritinophagy we found that intracellular ferrous iron levels in IB3-1 cells (but not C38 cells) increased following erastin and FAC exposure, which requires further investigation as the pathways responsible for this increase in redox active iron in response to ferroptotic induction are currently unknown, but will become targets for future treatment interventions