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Without adequate protein intake and resistance training, lean mass loss accompanies fat loss

A careful skeptic would say: the in-clinic procedure has solid evidence, the at-home extension is biologically plausible and consistent with the procedure, but the dataset is younger than the recommendation implies

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For instance, ERK phosphorylates Thr562 of MFN1, whereas Jun N-terminal kinase (JNK) upregulates the phosphorylation level of Ser27 in MFN2 [70, 71]