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USA 95 , 1202212027 (1998)

Recently, more attention is being given to the detrimental effects of chronic low-level exposure, especially to children

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In addition, it showed GSH-dependent high cytotoxicity on account of the rapid exhaust of intracellular GSH by both GSH depletion and biosynthesis inhibition

However, TACE creates a hypoxic microenvironment in the tumor that reduces the sensitivity of chemotherapy and plays a significant role in the unpredictable treatment outcome (126)