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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation [3]
[DOI] [PMC free article] [PubMed] [Google Scholar] 314.Elhassan, Y

When NNMT activity is high, NAD+ is depleted, metabolic rate slows, and fat accumulation increases

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