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Part of the reason is that anti-TNF agents block one specific cytokine while leaving the rest of the inflammatory network intact
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In the Ras pathway, Erk1/2 as two mitogen-activated protein kinases to transmit mitotic signals, and the HGF/c-Met signaling pathway phosphorylates and activates Erk1/2 after PHx (Spector et al., 1997
