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Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)

Recently, a class of proteins known as SIRTS or sirtuins (also known as silent information regulator 2 [Sir2]-related enzymes) has been implicated in an effect of CR on lifespan extension and the prevention of comorbidities associated with obesity [233, 234]
