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4-Hydroxynonenal (4-HNE) is an , unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker

Liver injury is a type of immune-related adverse event

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The synergistic inhibitory action of LC and TAU on the proliferation and osteoblastic differentiation of VSMCs is attributable to the up-regulation of TAUT expression and TAU uptake by LC.

Methods In this study, we design a two-in-one ferroptosis-inducing nanoplatform using iron-based metal-organic framework (MOF) that combines iron supply and GPX4 deactivation by loading the small molecule buthionine sulfoxide amine (BSO) to block de novo GSH biosynthesis, which can achieve sustainable GSH elimination and dual ferroptosis amplification

Methotrexate: Increased toxicity risk