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Together these data support the proposed mechanism that dihexa facilitates dimerization of HGF that subsequently activates the MET receptor and, subsequently, downstream intracellular signaling pathways 22

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Activated CAFs facilitate tumor cell growth, invasiveness, and drug resistance by depositing extracellular matrix (ECM) and secreting cytokines, chemokines, and growth factors (zdemir et al., 2014)

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