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Furthermore, an in vivo study observed that mice gavaged with zonulin showed increases in both small intestinal and gastroduodenal permeability compared with bovine serum albumin-treated controls (92)

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What the body does to drugs APPARENT VOLUME OF DISTRIBUTION BIOAVAILABILITY CLEARANCE ELIMINATION HALF LIFE LOADING DOSE MAINTENANCE DOSE CLINICAL CORRELATES: Drugs that are significantly metabolized with one pass through the liver (and have a large extraction ratio) will have a low bioavailability when given orally

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