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These insights have raised concerns regarding therapeutic strategies aimed at reducing mtDNA mutation load 3133 : although such approaches may benefit patients with mitochondrial diseases, they could simultaneously eliminate a natural protective barrier in pre-neoplastic tissues, thereby unmasking latent pro-tumorigenic potential

Modelos de reparacin de tejidos: estudios en animales informan mejores resultados en tendones, ligamentos, msculos, huesos y mucosa gastrointestinal

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379 Additionally, PTP4A2 regulates GBM recurrence via roundabout guidance receptor 1 (ROBO1), and CAR-T cell targeting of ROBO1 improves survival in recurrent GBM models, highlighting a potential therapeutic strategy for GBM