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Description
Phagocytic cells (e.g., neutrophils and macrophages) show a high concentration of VIC, which stimulates their migration to the site of infection and enhances phagocytosis, oxidant generation, and pathogen killing

Kesiktas, Fatma Nur, et al

These changes can lead to new discomfort, shifting bite patterns, or jaw and muscle pain

Goal: to summarize the mechanisms and clinical implications

If supportive measures such as supplementation, topical therapy, or sun protection are discontinued, pigmentation may gradually recur

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