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FIGURE 3 4.2 KRAS mutation in PDAC metabolic reprogramming KRAS mutation could accelerate PDAC progression depending on, not only the activation of signaling pathways, but also the induction of metabolic reprogramming ( KRAS mutation could regulate glucose, amino acid, and lipid metabolism in PDAC cancer cells (Suzuki et al., 2022)

Nat Rev Clin Oncol 8:467477 Daly FFS, OMalley GF, Heard K, Bogdan GM, Dart RC (2004) Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion