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doi: 10.1038/s12276-020-0394-0 63

In its response [15], the ACOG concluded that available studies show no clear evidence that proves a direct relationship between the prudent use of APAP during any trimester and fetal developmental issues. The ACOG further concluded that physicians should not change clinical practice until definitive prospective research is done. Considering the ACOG response, it is important to note that evidence of APAP inducing neurodevelopmental problems during the prenatal period is concerning but limited [2,16,17]

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The PROGNOSIS study [25] clearly demonstrated that sFlt-1/PlGF ratio of 38 or lower can be used to rule out the onset of preeclampsia within one week with a negative predictive value higher than 99%

385,386,387 Many CSF biomarkers (like A, P-tau, NfL, GFAP) also show promising applications in blood, with advancements in highly sensitive analytical platforms and detection techniques enhancing diagnostic precision and reliability

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