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However, chronic administration of 16 g oral pyridoxine per day for 1240 months can cause: severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements) which is dose dependent, and the symptoms usually stop if the patient discontinues the pyridoxine supplements as soon as the neurologic symptoms appear painful, disfiguring dermatological lesions photosensitivity gastrointestinal symptoms, such as nausea and heartburn Drug Interactions Vitamin B6 can interact with: Cycloserine: (Seromycin) is a broad-spectrum antibiotic used to treat tuberculosis

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