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These observations, reflecting regulatory effects on the transcriptional control of transporters affecting brain UA, demonstrate tissue-specific effects on UA activity, which further question the validity of MR studies discussed above
Toxicol Lett 2006
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these cofactors react with available functional groups on the substrates, reactive functional groups that are often generated by the phase 1 CYPs
Even though inflammatory reactions have been described as a potential problem in AAVs, they remain a preferred choice [176]
