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38 Both losartan, an angiotensin II receptor antagonist, and indomethacin, a non-selective cyclooxygenase antagonist, inhibited HDM-induced uric acid production in HBEC-6KT (Figure 7e,f)

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In addition, the absence of resistance of peptides to breakdown by gastrointestinal proteolytic enzymes (e.g., carboxypeptidases or aminopeptidases) should be mentioned [8], which in practice precludes administrating such a drug to the patient orally and calls for intravenous administration