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We previously showed that the stimulation of FAO cells derived from rat hepatoma with different doses of insulin led to selective responses with different insulin sensitivities including the regulation of induced and basal insulin stimulation across multiple omics 24,30

Other strategies preventing drug adaptation include the inhibition of AhR and SMAD3 with resveratrol 46 and SIS3 41 , respectively, leading to increased BRAFi and MEKi sensitivity

describe and define (quantitatively to the extent possible) the variability and uncertainty for key assumptions used for each key end-point-specific risk assessment (choices of data set, POD, model, and dose metric)

Serum HBsAg decline may be used as a surrogate to explore efficacy in early-phase trials, although its accuracy in predicting HBsAg loss has not been established

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