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Whether receptor downregulation or pathway adaptation occurs with chronic dosing is unknown

This functional disorder not only disrupts the normal regulatory mechanisms of blood vessels but also leads to increased blood pressure, arterial stiffness, and remodeling of small arteries, ultimately resulting in multi-organ damage (Boutouyrie et al., 2021

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Hormone Replacement Therapy Hormone Replacement Therapy (HRT) is a medical treatment designed to alleviate symptoms associated with hormonal imbalances, particularly those occurring during menopause and perimenopause

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