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Therefore in many organs, neuropeptides can exert effects through direct innervation of the end organ (synaptic contact), but also through non-synaptic contact and paracrine activity on neighboring cells [21]

This necessity imposes strict criteria on the encapsulating polymer, requiring it to be not only biocompatible and biodegradable but also permeable enough to allow for the critical bidirectional exchange of nutrients and metabolites that sustain probiotic life (277)

Also, metformin can be safely used with other drugs, including insulin

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Japan Patent Application JP2011234645 (A) Townsend DM, Tew KD, Tapiero H (2003) The importance of glutathione in human disease

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