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Collectively, these effects contribute to the mitigation of systemic risk in diabetic nephropathy, thereby reducing the overall burden of cardiovascular disease, a major complication in patients with DKD

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Notably, conflicting findings have been reported regarding the abundance of certain bacterial taxa (e.g., Megasphaera and Barnesiella ), potentially due to population heterogeneity, methodological variability, or confounding factors such as constipation and allergies (De Sales-Milln et al., 2024