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Cells lacking ergothioneine have shown increased susceptibility to oxidative stress, leading to heightened mitochondrial DNA damage (Lu et al., 2016)

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Journal of Translational Medicine, 23 , Article 650

When assessed behaviorally, MCT2-downregulated animals were impaired in a textured object recognition task, while a similar proportion of MCT4-downregulated animals (about half) showed an identical deficit, mirroring the bifurcation observed in the neurovascular responses

NF-kappaB protects lung epithelium against hyperoxia-induced nonapoptotic cell death-oncosis