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This interaction initiates the transcription of a broad array of cytoprotective genes, markedly enhancing the synthesis of intracellular glutathione and upregulating phase II detoxification and antioxidant enzymes, including glutathione S-transferases (GSTs) and heme oxygenase-1 (HO-1)

In a study conducted by Demir [21], the effects of the anti-epileptic drugs phenytoin, gabapentin, and primidone on the GR enzyme were investigated

Dong 2023)
Cureus 11(4):e4556
