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Gain-of-function mutations in oncogenes (such as RAS superfamily) or positive regulators (such as NF-B inducing kinase) contribute to sustained activation of NF-B signaling and subsequent cell proliferation

Moreover, recent studies have shown that GSTA4 expression is selectively downregulated in adipose tissue of obese insulin-resistant C57BL/6J mice and in human obesity-linked insulin resistance (Curtis et al., 2010)

doi: 10.3390/cells12091273

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ncRNA, noncoding RNA

doi:10.2147/IJGM.S16275