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When this ratio collapses, the cell enters a state of severe oxidative stress, leading to accelerated aging, mitochondrial dysfunction, and eventually, cellular death (apoptosis)

According to studies, p53-mediated reactions and the stimulation of polyamine metabolism can cause ferroptosis in naive B cells

Padmanabhan RV, Gudapaty R, Liener IE, Schwartz BA, Hoidal JR

Eo, H., Kim, S., Jung, U

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Some biomolecules involved in these processes have been determined to play key regulatory roles in AIH and provide promising targets for intervening APAP-induced liver injury