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This means that long term obesity may impair male fertility potential

doi: 10.1183/13993003.01033-2015 2 HenkleEChanBCurtisJRAksamitTRDaleyCLWinthropKL

In lung cancer, H19 downregulation significantly reduces clonogenicity and anchorage-independent growth, and it acts as a critical downstream effector of c-Myc to promote tumorigenesis [99,100,101]

The RNAi mechanism involves small interfering RNA molecules that efficiently down-regulate desired genes

As mentioned above, hyperglycemia induces oxidative stress, which may lead to endothelial dysfunction, mainly manifested in: Endothelial nitric oxide synthase (eNOS) activity is inhibited, NO synthesis is reduced, thrombosis factors (such as tissue factor and plasminogen activator inhibitors1) or ET-1 production is increased, which induces thrombosis and vasoconstriction, and nuclear factor kappaB (NF-B) and activator protein1 are increased, leading to tissue inflammation (Defeudis et al