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more or less, it may cause gastric ulceration [46]

Gradual Dose Increase Rapid dose escalation may increase gastrointestinal side effects
, pons/medullary regions) (Dhuria et al., 2010, Gnger and Schindowski, 2018, Illum, 2000, Pardeshi and Belgamwar, 2013, Pires et al., 2009)
It can be improved within 1-2 weeks, whereas some chronic diseases, such as arthritis or tissue regeneration, can require 4-6 weeks or more

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Minegishi H., Fukashiro S., Ban H.S., Nakamura H

, Deanfield, J